將醋酸、異丙醇和濃硫酸加入搪瓷釜，攪拌下加熱回流10h以上，降溫后用碳酸氫鈉或碳酸鈉飽和溶液中和pH值7～8，用飽和食鹽水溶液洗滌，再用水洗滌，靜置分去水層后，用無水硫酸鈉或硫酸鎂進(jìn)行干燥，過濾后加入精餾塔進(jìn)行精餾，收集85～95℃的餾分，即為成品。

精制方法：常含有水、乙酸和異丙醇等雜質(zhì)。精制時(shí)于100mL酯中加入50g碳酸鉀，充分搖動以除去酸。再用濃的氯化鈣溶液洗滌除去醇，無水氯化鈣干燥1晝夜后蒸餾。

1.主要用作涂料、印刷油墨等的溶劑，也是工業(yè)上常用的脫水劑，藥物生產(chǎn)中的萃取劑及香料組分；

2.主要用作藥物的提取溶劑、涂料溶劑、印刷油墨溶劑、化學(xué)反應(yīng)溶劑等。該品呈水果香氣，稀釋后有蘋果香氣，天然品存在于菠蘿、梨、可可等中，是中國GB2760-86規(guī)定為允許使用的食用香料。主要用以配制朗姆酒香精和水果型香料的溶劑。


浩瀚色譜（山東）應(yīng)用技術(shù)開發(fā)有限公司，采用填充柱10%聚己二酸乙二醇酯/401有機(jī)擔(dān)體測定工業(yè)乙酸異丙酯中雜質(zhì)：水分，異丙醇，乙酸異丙酯，柱效高，分離好，峰型對稱，結(jié)果滿意。


工業(yè)乙酸異丙酯的測定填充柱  測試譜圖：




Packed column for the determination of industrial isopropyl acetate
Packed column for the determination of industrial isopropyl acetate Details:

Name: Packed Column
Fixative: 10% polyethylene adipate

Carrier: 401 organic carrier (0.25mm-0.18mm)/60-80 mesh

Ratio: Carrier: Fixative = 100:10
Model: 10%PEA/401


Isopropyl acetate; 2-propyl acetate
Colorless transparent liquid with fruity fragrance. Volatile, miscible with most organic solvents such as alcohols, ketones and ethers. 2.9% by weight in water at 20°C.

chemical properties
It is flammable, its vapor and air can form explosive mixture. In case of open fire and high heat, it will cause combustion and explosion; it can react strongly with oxidants. Its vapor is heavier than air, and it can spread to a considerable distance at a lower place, and it will cause flashback in case of an open flame. Combustion (decomposition) products: carbon monoxide, carbon dioxide, and water.

Add acetic acid, isopropanol and concentrated sulfuric acid to the enamel kettle, heat to reflux for more than 10 hours with stirring, neutralize with sodium bicarbonate or saturated sodium carbonate solution to pH 7-8 after cooling, wash with saturated saline solution, then wash with water, and let After the water layer is removed, dried with anhydrous sodium sulfate or magnesium sulfate, filtered, and then added to a rectifying tower for rectification, and the fractions at 85 to 95°C are collected, which is the finished product.
Refining method: often contains impurities such as water, acetic acid and isopropanol. During purification, 50 g of potassium carbonate was added to 100 mL of ester and shaken well to remove the acid. Then wash with concentrated calcium chloride solution to remove alcohol, dry with anhydrous calcium chloride for 1 day and night, and then distill.


1. It is mainly used as a solvent for coatings, printing inks, etc., and is also a commonly used dehydrating agent in industry, an extractant and a fragrance component in pharmaceutical production;
2. Mainly used as extraction solvent of medicine, coating solvent, printing ink solvent, chemical reaction solvent, etc. The product has a fruity aroma, and has an apple aroma after dilution. The natural product exists in pineapple, pear, cocoa, etc. It is a permitted edible spice specified by China GB2760-86. It is mainly used to prepare the solvent of rum flavor and fruit flavor.


Haohan Chromatography (Shandong) Application Technology Development Co., Ltd. uses packed column 10% polyethylene adipate/401 organic support to determine impurities in industrial isopropyl acetate: moisture, isopropyl alcohol, isopropyl acetate, column efficiency High, the separation is good, the peak shape is symmetrical, and the results are satisfactory.


Determination of Industrial Isopropyl Acetate Packed Column Test Spectrum: